John's wort at the same time as taking any of these three drugs. But that does not mean that these drugs are safe for absolutely everyone. People who use Eliquis, Lixiana, and Xarelto are not likely to suffer drug-induced liver damage unless they are also treated with Lovenox, given by injection, almost always in a hospital setting. But Are Eliquis, Lixiana, and Xarelto Safe for Almost Everybody? When liver damage does occur, it seems to be associated less with the medication itself than with concomitant use low-molecular weight heparin (Lovenox) during hospital stays. The researchers found that the new medications Eliquis, Lixiana, and Xarelto are actually less likely to cause liver damage than Coumadin and Brilinta. Peak levels of the enzymes associated with liver destruction occur in the second or third month. When drug-induced liver injury occurs, it almost always occurs in the first six months the drug is used, enzyme levels rising after just one month. Only 1 to 2 people per 1000 users of these drugs, the researchers determined, is likely to develop drug-induced liver injury. Drug-induced liver injury, in general, is not a very common event, but it is a catastrophic event.
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